Abstract:

[Objective] This study investigates the operation modes of both international biological data-sharing service system and domestic scientific data sharing service system. It conducts an analysis from various aspects, including the collaborative operation mode of the system, policy support, financial support, management, infrastructure, scientific terminology and standards, as well as tools and technical systems. [Methods] The survey collects and analyzes a wide range of literature and resources related to the scientific data sharing system. Network searches and literature analysis methods are used. [Results] The operation modes of biological data sharing systems vary in different countries. Europe and the United States have been pioneers in establishing biological data sharing service systems, employing well-structured management frameworks that have fostered the development of robust ecological environments for biological data. The United States, Japan, and the United Kingdom have primarily adopted a centralized mode in their biological data centers, facilitating efficient resource management and monitoring through centralized mechanisms. In contrast, the biological sharing system in Switzerland operates through collaborative management involving multiple groups, which allows for team independence and cooperation. China currently lacks of a unified and effective biological data sharing system, thus requiring an acceleration in the construction. China has already accumulated experience and developed an effective management model during the establishment process of other scientific data sharing service systems. This experience can be leveraged to provide valuable insights for the construction of the biological data sharing system. [Conclusions] Through analyzing the existing operation modes, considering the distribution of biological data resources, as well as the characteristics of research and medical institutions and data security issues in China, it suggests that a hub-nodes joint mode should be adopted during the construction of a national biological data sharing system. Strengthening the construction of the hub node can provide essential support for construction of other nodes, ultimately establishing an interconnected network for biological data sharing. In terms of service system combining the management of cooperation mode, it is possible to promote cooperation in areas such as infrastructure, technical services, and research directions, thereby promoting the innovation of biomedical research.

Key words: biological data, sharing service system, data center, operational mode, data sharing